THC-COOH Metabolite

Louisiana Drugged Driving

a person is guilty of DUI if he drives a motor vehicle under the influence of a controlled dangerous substance.

First offense misdemeanor –
-fine of $300-$1,000 (plus fees);
- jail for a period of 10 days to 6 months (all jail time can be suspended);
- 32 hours of community service; 
- Substance abuse programs;
- License suspension for 90 days.


THC-COOH


Urinary Elimination of 

11-Nor-9-carboxy- 9-tetrahydrocannnabinol 

in Cannabis Users 

ncbi.nlm.nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587336/

The time course of

11-nor-9-carboxy-Δ9-tetrahydrocannnabinol (THCCOOH) 

elimination was characterized in 60 cannabis usersd during24 h monitored abstinence on a closed research unit for 30 days.

6,158 individual urine specimens were screened,
with values ≥50 ng/mL !
classified as positive. 

 in 40%, peaks occurred as long as 2.9 days after admission

First negative and last positive urine specimens; mean number of days were 3.2 and 9.7 days.

THC the major psychoactive component of cannabis, is rapidly metabolized
to the inactive metabolite THCCOOH.

An important issue for drug-testing programs is the ability to distinguish recent cannabis use from residual drug excretion.
Exceptionally long detection times have been reported for cannabinoid metabolites.

This makes interpretation of cannabinoid drug test results difficult to determine
whether positive results are indicative of
New drug use or
reflective of previous cannabis exposure.

Ellis et al. (9) reported that in one case, it took up to 77 days of abstinence for one individual to produce negative results
with a 20 ng/mL cutoff.!

_---------
blood tests can detect cannabinoid metabolites.
!
Not uncommonly, labs report levels of
THC-COOH, the non-psychoactive metabolite. !
!
THC-COOH levels may be detectable for a couple of days after a single use.

References:

Smoked dose based on data from M. Huestis , J. Henningfield and E. Cone,M. Huestis , J. Henningfield and E. Cone.


Huestis MA, Henningfield JE, Cone EJ (1992). "Blood cannabinoids. II. Models for the prediction of time of marijuana exposure from plasma concentrations of delta 9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (THCCOOH)". Journal of Analytical Toxicology. 16 (5): 283–90. doi:10.1093/jat/16.5.283. PMID 1338216.

Huestis MA, Mitchell JM, Cone EJ (October 1995). "Detection times of marijuana metabolites in urine by immunoassay and GC-MS". 
Journal of Analytical Toxicology. 19 (6): 443–9. 

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